![]() ![]() This model more closely mimics the structure and function of the human brain and key characteristics of Alzheimer’s disease than previous models, making it a powerful tool for understanding disease mechanisms and for developing drugs that target this devasting disease. ![]() Redefining Research: Serum-exposed brain organoids mimicked several characteristics of Alzheimer’s disease, such as plaques, tangles, and impaired neural networks. A new 3D model of the human nervous system is meant to mimic key processes in the development of the myelin sheath the fatty. An important feature of Alzheimer’s disease is blood-brain barrier leakage, which is characterized by exposure of the brain to serum, and which researchers set out to replicate in this nonanimal, patient-derived hiPSC model. Healthy for Humans: Efforts to develop drugs for Alzheimer’s disease have failed nearly every time, in part because of species differences between humans and the animals used to model the disease. Human brain atlases are indispensable tools to achieve a better understanding of the multilevel organization of the brain through integrating and analyzing data from different brains, sources, and modalities while considering the functionally relevant topography of the brain. Study in a Sentence: Researchers successfully modeled key characteristics of Alzheimer’s disease using a human induced pluripotent stem cell (hiPSC)-derived 3D brain organoid. ![]()
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